Santa Fe host River Plate in the CONMEBOL Sudamericana, Round of 16 at Estadio Nemesio Camacho El Campin, Bogota (36,343 capacity).

Santa Fe won 3, drew 1 and lost 1 of their previous 5 matches (W–W–D–W–L), scoring 10 and conceding 4.

River Plate lost all 5 matches (L–L–L–L–L), scoring 1 and conceding 7.

The two sides have met 9 times: Santa Fe 1 win, River Plate 3, 5 draws.